Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis
Identifieur interne : 000379 ( Main/Exploration ); précédent : 000378; suivant : 000380Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis
Auteurs : Stella G. Muthuri ; Sudhir Venkatesan ; Puja R. Myles ; Jo Leonardi-Bee ; Wei Shen Lim ; Abdullah Al Mamun ; Ashish P. Anovadiya ; Wildo N. Araújo ; Eduardo Azziz-Baumgartner ; Clarisa Báez ; Carlos Bantar ; Mazen M. Barhoush ; Matteo Bassetti [France] ; Bojana Beovic ; Roland Bingisser ; Isabelle Bonmarin [France] ; Victor H. Borja-Aburto ; Bin Cao [République populaire de Chine] ; Jordi Carratala ; María R. Cuezzo ; Justin T. Denholm ; Samuel R. Dominguez ; Pericles A. D. Duarte ; Gal Dubnov-Raz ; Marcela Echavarria ; Sergio Fanella ; James Fraser [Canada] ; Zhancheng Gao [République populaire de Chine] ; Patrick Gérardin [Réunion] ; Maddalena Giannella ; Sophie Gubbels ; Jethro Herberg ; Anjarath L. Higuera Iglesias ; Peter H. Hoeger ; Matthias Hoffmann ; Xiaoyun Hu ; Quazi T. Islam ; Mirela F. Jiménez ; Amr Kandeel ; Gerben Keijzers ; Hossein Khalili ; Gulam Khandaker ; Marian Knight [Royaume-Uni] ; Gabriela Kusznierz [Argentine] ; Ilija Kuzman ; Arthur M. C. Kwan ; Idriss Lahlou Amine ; Eduard Langenegger ; Kamran B. Lankarani ; Yee-Sin Leo ; Rita Linko ; Pei Liu [République populaire de Chine] ; Faris Madanat ; Toshie Manabe ; Elga Mayo-Montero ; Allison Mcgeer ; Ziad A. Memish ; Gokhan Metan ; Dragan Miki ; Kristin G. I. Mohn ; Ahmadreza Moradi ; Pagbajabyn Nymadawa ; Bulent Ozbay ; Mehpare Ozkan ; Dhruv Parekh ; Mical Paul ; Wolfgang Poeppl ; Fernando P. Polack ; Barbara A. Rath ; Alejandro H. Rodríguez ; Marilda M. Siqueira ; Joanna Skr T-Magierło ; Ewa Talarek ; Julian W. Tang ; Antoni Torres ; Selda H. Törün ; Dat Tran ; Timothy M. Uyeki ; Annelies Zwol ; Wendy Vaudry ; Daiva Velyvyte ; Tjasa Vidmar ; Paul Zarogoulidis ; Jonathan S. Nguyen-Van-TamSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2016-05.
Descripteurs français
- Wicri :
- topic : Hospitalisation.
English descriptors
- mix :
Abstract
Background The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. Methods A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. Results Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. Conclusions Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.
Url:
DOI: 10.1111/irv.12363
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Tang</name></author><author><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name></author><author><name sortKey="Torun, Selda H" sort="Torun, Selda H" uniqKey="Torun S" first="Selda H." last="Törün">Selda H. Törün</name></author><author><name sortKey="Tran, Dat" sort="Tran, Dat" uniqKey="Tran D" first="Dat" last="Tran">Dat Tran</name></author><author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name></author><author><name sortKey="Zwol, Annelies" sort="Zwol, Annelies" uniqKey="Zwol A" first="Annelies" last="Zwol">Annelies Zwol</name></author><author><name sortKey="Vaudry, Wendy" sort="Vaudry, Wendy" uniqKey="Vaudry W" first="Wendy" last="Vaudry">Wendy Vaudry</name></author><author><name sortKey="Velyvyte, Daiva" sort="Velyvyte, Daiva" uniqKey="Velyvyte D" first="Daiva" last="Velyvyte">Daiva Velyvyte</name></author><author><name sortKey="Vidmar, Tjasa" sort="Vidmar, Tjasa" uniqKey="Vidmar T" first="Tjasa" last="Vidmar">Tjasa Vidmar</name></author><author><name sortKey="Zarogoulidis, Paul" sort="Zarogoulidis, Paul" uniqKey="Zarogoulidis P" first="Paul" last="Zarogoulidis">Paul Zarogoulidis</name></author><author><name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01452880</idno><idno type="halId">hal-01452880</idno><idno type="halUri">https://hal.univ-reunion.fr/hal-01452880</idno><idno type="url">https://hal.univ-reunion.fr/hal-01452880</idno><idno type="doi">10.1111/irv.12363</idno><date when="2016-05">2016-05</date><idno type="wicri:Area/Hal/Corpus">000148</idno><idno type="wicri:Area/Hal/Curation">000148</idno><idno type="wicri:Area/Hal/Checkpoint">000087</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000087</idno><idno type="wicri:doubleKey">1750-2640:2016:Muthuri S:impact:of:neuraminidase</idno><idno type="wicri:Area/Main/Merge">000379</idno><idno type="wicri:Area/Main/Curation">000379</idno><idno type="wicri:Area/Main/Exploration">000379</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis</title><author><name sortKey="Muthuri, Stella G" sort="Muthuri, Stella G" uniqKey="Muthuri S" first="Stella G." last="Muthuri">Stella G. Muthuri</name></author><author><name sortKey="Venkatesan, Sudhir" sort="Venkatesan, Sudhir" uniqKey="Venkatesan S" first="Sudhir" last="Venkatesan">Sudhir Venkatesan</name></author><author><name sortKey="Myles, Puja R" sort="Myles, Puja R" uniqKey="Myles P" first="Puja R." last="Myles">Puja R. Myles</name></author><author><name sortKey="Leonardi Bee, Jo" sort="Leonardi Bee, Jo" uniqKey="Leonardi Bee J" first="Jo" last="Leonardi-Bee">Jo Leonardi-Bee</name></author><author><name sortKey="Lim, Wei Shen" sort="Lim, Wei Shen" uniqKey="Lim W" first="Wei Shen" last="Lim">Wei Shen Lim</name></author><author><name sortKey="Al Mamun, Abdullah" sort="Al Mamun, Abdullah" uniqKey="Al Mamun A" first="Abdullah" last="Al Mamun">Abdullah Al Mamun</name></author><author><name sortKey="Anovadiya, Ashish P" sort="Anovadiya, Ashish P" uniqKey="Anovadiya A" first="Ashish P." last="Anovadiya">Ashish P. Anovadiya</name></author><author><name sortKey="Araujo, Wildo N" sort="Araujo, Wildo N" uniqKey="Araujo W" first="Wildo N." last="Araújo">Wildo N. Araújo</name></author><author><name sortKey="Azziz Baumgartner, Eduardo" sort="Azziz Baumgartner, Eduardo" uniqKey="Azziz Baumgartner E" first="Eduardo" last="Azziz-Baumgartner">Eduardo Azziz-Baumgartner</name></author><author><name sortKey="Baez, Clarisa" sort="Baez, Clarisa" uniqKey="Baez C" first="Clarisa" last="Báez">Clarisa Báez</name></author><author><name sortKey="Bantar, Carlos" sort="Bantar, Carlos" uniqKey="Bantar C" first="Carlos" last="Bantar">Carlos Bantar</name></author><author><name sortKey="Barhoush, Mazen M" sort="Barhoush, Mazen M" uniqKey="Barhoush M" first="Mazen M." last="Barhoush">Mazen M. Barhoush</name></author><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-341508" status="INCOMING"> <orgName>University Hospital "Santa Maria della Misericordia"</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Beovic, Bojana" sort="Beovic, Bojana" uniqKey="Beovic B" first="Bojana" last="Beovic">Bojana Beovic</name></author><author><name sortKey="Bingisser, Roland" sort="Bingisser, Roland" uniqKey="Bingisser R" first="Roland" last="Bingisser">Roland Bingisser</name></author><author><name sortKey="Bonmarin, Isabelle" sort="Bonmarin, Isabelle" uniqKey="Bonmarin I" first="Isabelle" last="Bonmarin">Isabelle Bonmarin</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300053" status="VALID"> <orgName>Institut de Veille Sanitaire </orgName> <orgName type="acronym">INVS</orgName> <desc> <address> <addrLine>12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Borja Aburto, Victor H" sort="Borja Aburto, Victor H" uniqKey="Borja Aburto V" first="Victor H." last="Borja-Aburto">Victor H. Borja-Aburto</name></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-222142" status="INCOMING"> <orgName>Beijing Chao-Yang Hospital</orgName> <desc> <address> <addrLine>Beijing</addrLine> <country key="CN"></country> </address> </desc> <listRelation> <relation active="#struct-354012" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-354012" type="direct"><org type="institution" xml:id="struct-354012" status="INCOMING"> <orgName>Beijing Institute of Respiratory Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Carratala, Jordi" sort="Carratala, Jordi" uniqKey="Carratala J" first="Jordi" last="Carratala">Jordi Carratala</name></author><author><name sortKey="Cuezzo, Maria R" sort="Cuezzo, Maria R" uniqKey="Cuezzo M" first="María R." last="Cuezzo">María R. 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Kingston, Ontario</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.queensu.ca</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Gao, Zhancheng" sort="Gao, Zhancheng" uniqKey="Gao Z" first="Zhancheng" last="Gao">Zhancheng Gao</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-222150" status="INCOMING"> <orgName>Peking University People's Hospital</orgName> <desc> <address> <addrLine>Beijing</addrLine> <country key="CN"></country> </address> </desc> <listRelation> <relation active="#struct-354017" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-354017" type="direct"><org type="institution" xml:id="struct-354017" status="INCOMING"> <orgName>Peking University People's Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Gerardin, Patrick" sort="Gerardin, Patrick" uniqKey="Gerardin P" first="Patrick" last="Gérardin">Patrick Gérardin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-418783" status="VALID"> <idno type="RNSR">201521693U</idno> <orgName>Processus Infectieux en Milieu Insulaire Tropical</orgName> <orgName type="acronym">PIMIT</orgName> <desc> <address> <addrLine>Plateforme de recherche CYROI - 2 rue Maxime-Rivière 97491 Sainte Clotilde - La Réunion </addrLine> <country key="RE"></country> </address> <ref type="url">http://www.crvoi.org/</ref> </desc> <listRelation> <relation name="UMR9192" active="#struct-441569" type="direct"></relation> <relation name="UMR249" active="#struct-365853" type="direct"></relation> <relation name="U1187" active="#struct-303623" type="direct"></relation> <relation name="UM134" active="#struct-300316" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR9192" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UMR249" active="#struct-365853" type="direct"><org type="institution" xml:id="struct-365853" status="INCOMING"> <orgName>IRD</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle name="U1187" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="UM134" active="#struct-300316" type="direct"><org type="institution" xml:id="struct-300316" status="VALID"> <orgName>Université de La Réunion</orgName> <orgName type="acronym">UR</orgName> <desc> <address> <addrLine>15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9</addrLine> <country key="RE"></country> </address> <ref type="url">http://www.univ-reunion.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Réunion</country></affiliation></author><author><name sortKey="Giannella, Maddalena" sort="Giannella, Maddalena" uniqKey="Giannella M" first="Maddalena" last="Giannella">Maddalena Giannella</name></author><author><name sortKey="Gubbels, Sophie" sort="Gubbels, Sophie" uniqKey="Gubbels S" first="Sophie" last="Gubbels">Sophie Gubbels</name></author><author><name sortKey="Herberg, Jethro" sort="Herberg, Jethro" uniqKey="Herberg J" first="Jethro" last="Herberg">Jethro Herberg</name></author><author><name sortKey="Higuera Iglesias, Anjarath L" sort="Higuera Iglesias, Anjarath L" uniqKey="Higuera Iglesias A" first="Anjarath L." last="Higuera Iglesias">Anjarath L. 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Memish</name></author><author><name sortKey="Metan, Gokhan" sort="Metan, Gokhan" uniqKey="Metan G" first="Gokhan" last="Metan">Gokhan Metan</name></author><author><name sortKey="Miki, Dragan" sort="Miki, Dragan" uniqKey="Miki D" first="Dragan" last="Miki">Dragan Miki</name></author><author><name sortKey="Mohn, Kristin G I" sort="Mohn, Kristin G I" uniqKey="Mohn K" first="Kristin G. I." last="Mohn">Kristin G. I. Mohn</name></author><author><name sortKey="Moradi, Ahmadreza" sort="Moradi, Ahmadreza" uniqKey="Moradi A" first="Ahmadreza" last="Moradi">Ahmadreza Moradi</name></author><author><name sortKey="Nymadawa, Pagbajabyn" sort="Nymadawa, Pagbajabyn" uniqKey="Nymadawa P" first="Pagbajabyn" last="Nymadawa">Pagbajabyn Nymadawa</name></author><author><name sortKey="Ozbay, Bulent" sort="Ozbay, Bulent" uniqKey="Ozbay B" first="Bulent" last="Ozbay">Bulent Ozbay</name></author><author><name sortKey="Ozkan, Mehpare" sort="Ozkan, Mehpare" uniqKey="Ozkan M" first="Mehpare" last="Ozkan">Mehpare Ozkan</name></author><author><name sortKey="Parekh, Dhruv" sort="Parekh, Dhruv" uniqKey="Parekh D" first="Dhruv" last="Parekh">Dhruv Parekh</name></author><author><name sortKey="Paul, Mical" sort="Paul, Mical" uniqKey="Paul M" first="Mical" last="Paul">Mical Paul</name></author><author><name sortKey="Poeppl, Wolfgang" sort="Poeppl, Wolfgang" uniqKey="Poeppl W" first="Wolfgang" last="Poeppl">Wolfgang Poeppl</name></author><author><name sortKey="Polack, Fernando P" sort="Polack, Fernando P" uniqKey="Polack F" first="Fernando P." last="Polack">Fernando P. Polack</name></author><author><name sortKey="Rath, Barbara A" sort="Rath, Barbara A" uniqKey="Rath B" first="Barbara A." last="Rath">Barbara A. Rath</name></author><author><name sortKey="Rodriguez, Alejandro H" sort="Rodriguez, Alejandro H" uniqKey="Rodriguez A" first="Alejandro H." last="Rodríguez">Alejandro H. Rodríguez</name></author><author><name sortKey="Siqueira, Marilda M" sort="Siqueira, Marilda M" uniqKey="Siqueira M" first="Marilda M." last="Siqueira">Marilda M. Siqueira</name></author><author><name sortKey="Skr T Magierlo, Joanna" sort="Skr T Magierlo, Joanna" uniqKey="Skr T Magierlo J" first="Joanna" last="Skr T-Magierło">Joanna Skr T-Magierło</name></author><author><name sortKey="Talarek, Ewa" sort="Talarek, Ewa" uniqKey="Talarek E" first="Ewa" last="Talarek">Ewa Talarek</name></author><author><name sortKey="Tang, Julian W" sort="Tang, Julian W" uniqKey="Tang J" first="Julian W." last="Tang">Julian W. Tang</name></author><author><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name></author><author><name sortKey="Torun, Selda H" sort="Torun, Selda H" uniqKey="Torun S" first="Selda H." last="Törün">Selda H. Törün</name></author><author><name sortKey="Tran, Dat" sort="Tran, Dat" uniqKey="Tran D" first="Dat" last="Tran">Dat Tran</name></author><author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name></author><author><name sortKey="Zwol, Annelies" sort="Zwol, Annelies" uniqKey="Zwol A" first="Annelies" last="Zwol">Annelies Zwol</name></author><author><name sortKey="Vaudry, Wendy" sort="Vaudry, Wendy" uniqKey="Vaudry W" first="Wendy" last="Vaudry">Wendy Vaudry</name></author><author><name sortKey="Velyvyte, Daiva" sort="Velyvyte, Daiva" uniqKey="Velyvyte D" first="Daiva" last="Velyvyte">Daiva Velyvyte</name></author><author><name sortKey="Vidmar, Tjasa" sort="Vidmar, Tjasa" uniqKey="Vidmar T" first="Tjasa" last="Vidmar">Tjasa Vidmar</name></author><author><name sortKey="Zarogoulidis, Paul" sort="Zarogoulidis, Paul" uniqKey="Zarogoulidis P" first="Paul" last="Zarogoulidis">Paul Zarogoulidis</name></author><author><name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name></author></analytic><idno type="DOI">10.1111/irv.12363</idno><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><imprint><date type="datePub">2016-05</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> Open Access</term><term> individual participant data meta-analyses</term><term> influenza-related pneumonia</term><term> neuraminidase inhibitors</term><term>Hospitalisation</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Hospitalisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Background The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. Methods A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. Results Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. Conclusions Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.</p> </div></front></TEI><affiliations><list><country><li>Argentine</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Réunion</li></country></list><tree><noCountry><name sortKey="Al Mamun, Abdullah" sort="Al Mamun, Abdullah" uniqKey="Al Mamun A" first="Abdullah" last="Al Mamun">Abdullah Al Mamun</name><name sortKey="Anovadiya, Ashish P" sort="Anovadiya, Ashish P" uniqKey="Anovadiya A" first="Ashish P." last="Anovadiya">Ashish P. Anovadiya</name><name sortKey="Araujo, Wildo N" sort="Araujo, Wildo N" uniqKey="Araujo W" first="Wildo N." last="Araújo">Wildo N. Araújo</name><name sortKey="Azziz Baumgartner, Eduardo" sort="Azziz Baumgartner, Eduardo" uniqKey="Azziz Baumgartner E" first="Eduardo" last="Azziz-Baumgartner">Eduardo Azziz-Baumgartner</name><name sortKey="Baez, Clarisa" sort="Baez, Clarisa" uniqKey="Baez C" first="Clarisa" last="Báez">Clarisa Báez</name><name sortKey="Bantar, Carlos" sort="Bantar, Carlos" uniqKey="Bantar C" first="Carlos" last="Bantar">Carlos Bantar</name><name sortKey="Barhoush, Mazen M" sort="Barhoush, Mazen M" uniqKey="Barhoush M" first="Mazen M." last="Barhoush">Mazen M. Barhoush</name><name sortKey="Beovic, Bojana" sort="Beovic, Bojana" uniqKey="Beovic B" first="Bojana" last="Beovic">Bojana Beovic</name><name sortKey="Bingisser, Roland" sort="Bingisser, Roland" uniqKey="Bingisser R" first="Roland" last="Bingisser">Roland Bingisser</name><name sortKey="Borja Aburto, Victor H" sort="Borja Aburto, Victor H" uniqKey="Borja Aburto V" first="Victor H." last="Borja-Aburto">Victor H. Borja-Aburto</name><name sortKey="Carratala, Jordi" sort="Carratala, Jordi" uniqKey="Carratala J" first="Jordi" last="Carratala">Jordi Carratala</name><name sortKey="Cuezzo, Maria R" sort="Cuezzo, Maria R" uniqKey="Cuezzo M" first="María R." last="Cuezzo">María R. Cuezzo</name><name sortKey="Denholm, Justin T" sort="Denholm, Justin T" uniqKey="Denholm J" first="Justin T." last="Denholm">Justin T. Denholm</name><name sortKey="Dominguez, Samuel R" sort="Dominguez, Samuel R" uniqKey="Dominguez S" first="Samuel R." last="Dominguez">Samuel R. Dominguez</name><name sortKey="Duarte, Pericles A D" sort="Duarte, Pericles A D" uniqKey="Duarte P" first="Pericles A. D." last="Duarte">Pericles A. D. Duarte</name><name sortKey="Dubnov Raz, Gal" sort="Dubnov Raz, Gal" uniqKey="Dubnov Raz G" first="Gal" last="Dubnov-Raz">Gal Dubnov-Raz</name><name sortKey="Echavarria, Marcela" sort="Echavarria, Marcela" uniqKey="Echavarria M" first="Marcela" last="Echavarria">Marcela Echavarria</name><name sortKey="Fanella, Sergio" sort="Fanella, Sergio" uniqKey="Fanella S" first="Sergio" last="Fanella">Sergio Fanella</name><name sortKey="Giannella, Maddalena" sort="Giannella, Maddalena" uniqKey="Giannella M" first="Maddalena" last="Giannella">Maddalena Giannella</name><name sortKey="Gubbels, Sophie" sort="Gubbels, Sophie" uniqKey="Gubbels S" first="Sophie" last="Gubbels">Sophie Gubbels</name><name sortKey="Herberg, Jethro" sort="Herberg, Jethro" uniqKey="Herberg J" first="Jethro" last="Herberg">Jethro Herberg</name><name sortKey="Higuera Iglesias, Anjarath L" sort="Higuera Iglesias, Anjarath L" uniqKey="Higuera Iglesias A" first="Anjarath L." last="Higuera Iglesias">Anjarath L. Higuera Iglesias</name><name sortKey="Hoeger, Peter H" sort="Hoeger, Peter H" uniqKey="Hoeger P" first="Peter H." last="Hoeger">Peter H. Hoeger</name><name sortKey="Hoffmann, Matthias" sort="Hoffmann, Matthias" uniqKey="Hoffmann M" first="Matthias" last="Hoffmann">Matthias Hoffmann</name><name sortKey="Hu, Xiaoyun" sort="Hu, Xiaoyun" uniqKey="Hu X" first="Xiaoyun" last="Hu">Xiaoyun Hu</name><name sortKey="Islam, Quazi T" sort="Islam, Quazi T" uniqKey="Islam Q" first="Quazi T." last="Islam">Quazi T. Islam</name><name sortKey="Jimenez, Mirela F" sort="Jimenez, Mirela F" uniqKey="Jimenez M" first="Mirela F." last="Jiménez">Mirela F. 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Kwan</name><name sortKey="Lahlou Amine, Idriss" sort="Lahlou Amine, Idriss" uniqKey="Lahlou Amine I" first="Idriss" last="Lahlou Amine">Idriss Lahlou Amine</name><name sortKey="Langenegger, Eduard" sort="Langenegger, Eduard" uniqKey="Langenegger E" first="Eduard" last="Langenegger">Eduard Langenegger</name><name sortKey="Lankarani, Kamran B" sort="Lankarani, Kamran B" uniqKey="Lankarani K" first="Kamran B." last="Lankarani">Kamran B. 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Memish</name><name sortKey="Metan, Gokhan" sort="Metan, Gokhan" uniqKey="Metan G" first="Gokhan" last="Metan">Gokhan Metan</name><name sortKey="Miki, Dragan" sort="Miki, Dragan" uniqKey="Miki D" first="Dragan" last="Miki">Dragan Miki</name><name sortKey="Mohn, Kristin G I" sort="Mohn, Kristin G I" uniqKey="Mohn K" first="Kristin G. I." last="Mohn">Kristin G. I. Mohn</name><name sortKey="Moradi, Ahmadreza" sort="Moradi, Ahmadreza" uniqKey="Moradi A" first="Ahmadreza" last="Moradi">Ahmadreza Moradi</name><name sortKey="Muthuri, Stella G" sort="Muthuri, Stella G" uniqKey="Muthuri S" first="Stella G." last="Muthuri">Stella G. Muthuri</name><name sortKey="Myles, Puja R" sort="Myles, Puja R" uniqKey="Myles P" first="Puja R." last="Myles">Puja R. Myles</name><name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name><name sortKey="Nymadawa, Pagbajabyn" sort="Nymadawa, Pagbajabyn" uniqKey="Nymadawa P" first="Pagbajabyn" last="Nymadawa">Pagbajabyn Nymadawa</name><name sortKey="Ozbay, Bulent" sort="Ozbay, Bulent" uniqKey="Ozbay B" first="Bulent" last="Ozbay">Bulent Ozbay</name><name sortKey="Ozkan, Mehpare" sort="Ozkan, Mehpare" uniqKey="Ozkan M" first="Mehpare" last="Ozkan">Mehpare Ozkan</name><name sortKey="Parekh, Dhruv" sort="Parekh, Dhruv" uniqKey="Parekh D" first="Dhruv" last="Parekh">Dhruv Parekh</name><name sortKey="Paul, Mical" sort="Paul, Mical" uniqKey="Paul M" first="Mical" last="Paul">Mical Paul</name><name sortKey="Poeppl, Wolfgang" sort="Poeppl, Wolfgang" uniqKey="Poeppl W" first="Wolfgang" last="Poeppl">Wolfgang Poeppl</name><name sortKey="Polack, Fernando P" sort="Polack, Fernando P" uniqKey="Polack F" first="Fernando P." last="Polack">Fernando P. Polack</name><name sortKey="Rath, Barbara A" sort="Rath, Barbara A" uniqKey="Rath B" first="Barbara A." last="Rath">Barbara A. Rath</name><name sortKey="Rodriguez, Alejandro H" sort="Rodriguez, Alejandro H" uniqKey="Rodriguez A" first="Alejandro H." last="Rodríguez">Alejandro H. Rodríguez</name><name sortKey="Siqueira, Marilda M" sort="Siqueira, Marilda M" uniqKey="Siqueira M" first="Marilda M." last="Siqueira">Marilda M. Siqueira</name><name sortKey="Skr T Magierlo, Joanna" sort="Skr T Magierlo, Joanna" uniqKey="Skr T Magierlo J" first="Joanna" last="Skr T-Magierło">Joanna Skr T-Magierło</name><name sortKey="Talarek, Ewa" sort="Talarek, Ewa" uniqKey="Talarek E" first="Ewa" last="Talarek">Ewa Talarek</name><name sortKey="Tang, Julian W" sort="Tang, Julian W" uniqKey="Tang J" first="Julian W." last="Tang">Julian W. Tang</name><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name><name sortKey="Torun, Selda H" sort="Torun, Selda H" uniqKey="Torun S" first="Selda H." last="Törün">Selda H. Törün</name><name sortKey="Tran, Dat" sort="Tran, Dat" uniqKey="Tran D" first="Dat" last="Tran">Dat Tran</name><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name><name sortKey="Vaudry, Wendy" sort="Vaudry, Wendy" uniqKey="Vaudry W" first="Wendy" last="Vaudry">Wendy Vaudry</name><name sortKey="Velyvyte, Daiva" sort="Velyvyte, Daiva" uniqKey="Velyvyte D" first="Daiva" last="Velyvyte">Daiva Velyvyte</name><name sortKey="Venkatesan, Sudhir" sort="Venkatesan, Sudhir" uniqKey="Venkatesan S" first="Sudhir" last="Venkatesan">Sudhir Venkatesan</name><name sortKey="Vidmar, Tjasa" sort="Vidmar, Tjasa" uniqKey="Vidmar T" first="Tjasa" last="Vidmar">Tjasa Vidmar</name><name sortKey="Zarogoulidis, Paul" sort="Zarogoulidis, Paul" uniqKey="Zarogoulidis P" first="Paul" last="Zarogoulidis">Paul Zarogoulidis</name><name sortKey="Zwol, Annelies" sort="Zwol, Annelies" uniqKey="Zwol A" first="Annelies" last="Zwol">Annelies Zwol</name></noCountry><country name="France"><noRegion><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name></noRegion><name sortKey="Bonmarin, Isabelle" sort="Bonmarin, Isabelle" uniqKey="Bonmarin I" first="Isabelle" last="Bonmarin">Isabelle Bonmarin</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name></noRegion><name sortKey="Gao, Zhancheng" sort="Gao, Zhancheng" uniqKey="Gao Z" first="Zhancheng" last="Gao">Zhancheng Gao</name><name sortKey="Liu, Pei" sort="Liu, Pei" uniqKey="Liu P" first="Pei" last="Liu">Pei Liu</name></country><country name="Canada"><noRegion><name sortKey="Fraser, James" sort="Fraser, James" uniqKey="Fraser J" first="James" last="Fraser">James Fraser</name></noRegion></country><country name="Réunion"><noRegion><name sortKey="Gerardin, Patrick" sort="Gerardin, Patrick" uniqKey="Gerardin P" first="Patrick" last="Gérardin">Patrick Gérardin</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Knight, Marian" sort="Knight, Marian" uniqKey="Knight M" first="Marian" last="Knight">Marian Knight</name></noRegion></country><country name="Argentine"><noRegion><name sortKey="Kusznierz, Gabriela" sort="Kusznierz, Gabriela" uniqKey="Kusznierz G" first="Gabriela" last="Kusznierz">Gabriela Kusznierz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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